Table 1.
Baseline characteristics based on smoking status.
| Never-smokers (n = 256) |
Ever-smokers (n = 487) |
P-value | |
|---|---|---|---|
| Age | |||
| <60 years | 74 (28.9%) | 118 (24.2%) | 0.1 |
| ≥60 years | 182 (71.1%) | 369 (75.8%) | |
| WHO classification | |||
| RA | 54 (21.1%) | 108 (22.2%) | 0.06 |
| RARS | 28 (10.9%) | 63 (12.9%) | |
| RCMD | 61 (23.8%) | 80 (16.4%) | |
| RAEB | 96 (37.5%) | 213 (43.7%) | |
| Del 5q | 7 (2.7%) | 15 (3.1%) | |
| Karyotype | |||
| Good | 160 (62.5%) | 275 (56.5%) | 0.1 |
| Intermediate | 36 (14.1%) | 80 (16.4%) | |
| Poor | 42 (16.4%) | 109 (22.4%) | |
| Missing | 18 (7%) | 23 (4.7%) | |
| MD Anderson risk | |||
| Low | 61 (23.8%) | 95 (19.5%) | 0.35 |
| Intermediate-1 | 85 (33.2%) | 147 (30.2%) | |
| Intermediate-2 | 48 (18.8%) | 102 (20.9%) | |
| High | 35 (13.7%) | 88 (18.1%) | |
| Missing | 27 (10.5%) | 55 (11.3%) | |
| RBC-TD | |||
| Yes | 116 (45.3%) | 230 (47.7%) | 0.7 |
| HMA treatment | |||
| Yes | 115 (49.9%) | 248 (50.9%) | 0.07 |
| IPSS | |||
| Low | 55 (24%) | 87 (20.3%) | 0.6 |
| Intermediate-1 | 113 (49.3%) | 209 (48.7%) | |
| Intermediate-2 | 49 (21.4%) | 106 (24.7%) | |
| High | 12 (5.5%) | 27 (6.3%) | |
| Ferritin ≥1000 ng/mL | 61 (35.9%) | 104 (31.8%) | 0.2 |
HMA, hypomethylating agent; IPSS, International Prognostic Scoring System; RA, refractory anemia; RARS, refractory anemia with ringed sideroblasts; RCMD, refractory cytopenia with multilineage dysplasia; RAEB, refractory anemia with excess blasts; RBC-TD, red blood cell transfusion dependence; WHO, World Health Organization.