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. 2018 Jul;46(7):1014–1022. doi: 10.1124/dmd.117.078360

Fig. 3.

Fig. 3.

The intraperitoneal ketamine-induced dLORR significantly increases in mice with absent or inhibited Pgp and Bcrp. (A) Comparison of ketamine-induced (100 mg/kg body weight, i.p.) dLORR in WT, Bcrp KO, Pgp KO, and dKO FVB mice. (B) Ketamine-induced (50, 100 and 200 mg/kg body weight, i.p.) dLORR in WT mice with or without 1.5-hour pretreatment with elacridar (100 mg/kg body weight). Results are expressed as the median dLORR ± range. Significance was calculated using the Mann–Whitney test. *P < 0.05; ***P < 0.001. ECD, elacridar; IP, intraperitoneal.