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. 2018 Jun 1;9:1082. doi: 10.3389/fimmu.2018.01082

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Copyright © 2018 Wilkinson and Leishman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed mechanism of action of MEDI9197 following intratumoural administration. MEDI9197 activates toll-like receptor (TLR) 7 and 8 expressing cells, such as plasmacytoid dendritic cells (pDC), myeloid dendritic cells (mDC), and monocytes (Mo), which release type I interferons and pro-inflammatory cytokines, such as interleukin-12 (IL-12); leading to recruitment and activation of effector cells, including natural killer (NK) cells and cytotoxic T lymphocytes (CTL) to the tumor. The activated effector cells release interferon gamma (IFN-γ), perforin, and granzymes to kill the tumor cells.