Table 1.
Residual morphine (μg) (±SEM) | ||||||
---|---|---|---|---|---|---|
Tissue |
8 week |
24 week |
p value |
8 week |
24 week |
p value |
per tissue weight(g) | per tissue weight(g) | per protein content(g) | per protein content(g) | |||
Serum | 4.47±1.72 | 23.32±1.61 | >0.05 | 0.49±0.12 | 3.39±0.34 | <0.0001 |
Spleen | 22.45±2.93 | 68.41±7.05 | <0.001 | 0.89±0.14 | 4.63±0.35 | <0.0001 |
Kidney | 58.66±5.65 | 56.14±5.95 | >0.05 | 2.42±0.53 | 4.23±0.15 | <0.05 |
Liver | 40.12±6.46 | 44.52±1.01 | >0.05 | 3.25±0.37 | 2.81±0.71 | >0.05 |
Heart | 1.62±0.31 | 20.49±2.31 | <0.0001 | 0.43±0.31 | 1.20±0.62 | >0.05 |
Lungs | 17.38±3.61 | 63.22±14.8 | <0.001 | 0.96±0.32 | 2.28±0.54 | >0.05 |
Brain | 1.21±0.49 | 7.47±0.82 | <0.05 | 0.25±0.11 | 0.41±0.18 | >0.05 |