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. 2018 Jan 5;50(1):e422. doi: 10.1038/emm.2017.175

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Effect of S100A4 cell depletion on hepatic oval cell hyperplasia (a) and bile duct hyperplasia (b). Both were accessed on 1 to 4 scale, score 0 for no lesion, 1 for lesion affects less than 10% of the tissue, 2 for lesion affects 10–20% of the tissue, 3 for lesion affects 20–40% of the tissue and 4 for lesion affects 40–100% of the tissue. (c) Representative images showing hepatic oval cell hyperplasia in PTEN-TK⁻ and PTEN-TK⁺ mice.