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. 2018 Jan 5;50(1):e422. doi: 10.1038/emm.2017.175

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Copyright © 2018 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Effect of S100A4 cell depletion on hepatic histopathology. (a) Modified NAS is the Sum of marcrosteatosis, microsteatosis, inflammation and ballooning scores. (b) Liver fibrosis stage was individually scored as 0 for no fibrosis, 1 for periportal or perivenular fibrosis, 2 for periportal and perivenular, 3 for bridging fibrosis and 4 for cirrhosis. (c, d) Steatosis was individually scored by macrosteatosis (c) and microsteatosis (d) (0 for <5%, 1 for 5–33%, 2 for 33–66%, and 3 for more than 66%). (e) Inflammation was graded by overall assessment of all inflammatory foci (0 for no foci, 1 for <2, 2 for 2–4 foci, and 3 for >4 foci). (f) Ballooning score was 0 for no ballooned cells per field, 1 for few, and 2 for many.