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. 2018 Jan 5;50(1):e418. doi: 10.1038/emm.2017.159

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Copyright © 2018 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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The putative signaling pathway composed of FOXM1, MYC and miR-34a. Upregulated genes in the FOXM1-high (FH) subgroup are indicated in red. The intensity of color is indicative of the degree of overexpression. Orange- or blue-colored elements indicate predicted activation or inhibition, respectively. Each line and arrow represents the functional and physical interactions between the genes and the direction of regulation reported in the literature. The networks were generated using the Ingenuity Pathways Analysis tool (www.ingenuity.com).