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. 2018 May 24;11:167. doi: 10.3389/fnmol.2018.00167

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Copyright © 2018 Schaefer, Zheng, van Brederode, Berger, Leacock, Hirata, Paige, Harvey, Alzheimer and Villmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Backcross of shaky mouse line into the spasmodic mouse line. Developmental expression of the GlyR α1 subunit in shaky mice and after backcross into the mouse line spasmodic (A–D). After backcross of shaky into the spasmodic line, the expression profile was determined in spinal cord (sc), brain stem (bs) and cortex (cx) for stages P0, P7, P14, P28, P56, P84, and P100. (A) Glra1^+/+, (B) Glra1^sh/spd, (C) heterozygous Glra1^+/spd, and (D) heterozygous Glra1^+/sh. Cortex (cx) served as negative control for GlyR α1. GlyR α1 subunit was stained with mAb2b (48 kDa), and β-Actin (46 kDa) served as a loading control (LC). Cortex samples were probed with a GlyR pan-α antibody (mAb4a) labeling other GlyR α subunits in the cortex (A,B).