Table 1.

Possible risk factors for the development of SGLT-2 inhibitor-associated DKA (24).

Surgical procedures

Vigorous exercise

Acute illness e.g. myocardial infarction, infection

Prolonged fasting

Beta cell failure i.e. LADA, type 1 diabetes and prolonged type 2 diabetes

Dehydration

Reduction in dosing or discontinuation of insulin

Weight loss

Alcohol

DKA, diabetic ketoacidosis; LADA, latent-onset autoimmune diabetes in adults; SGLT-2, sodium glucose co-transporter.