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. 2018 May 24;13(5):e0198039. doi: 10.1371/journal.pone.0198039

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© 2018 Shimada et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 6 — (A) Electron microscopic analysis of the blood-brain barrier on the non-ischemic side of tPA- (contralateral tPA, n = 3), ischemic side of tPA- (tPA, n = 3), and ischemic side of tPA plus prHSP27- (tPA and prHSP27, n = 3) treated mice. Magnification, ×5000 (left row) and ×15000 (right row). The left row shows magnifications of the boxed areas in the right row. Scale bars, 1 μm (left row) and 500 nm (right row). a: astrocyte endfeet; e: endothelial cell; L: lumen. Arrowheads: the space between the basement membrane and astrocyte endfeet. Asterisks indicate the space between the basement membrane and astrocyte endfeet (B).