Table 8. Variation coefficients regarding the robustness evaluation of the dissolution test.
Condition | Time (min) | Variation coefficient (CV%) |
---|---|---|
32 °C; 75 rpm | 05 | 12.48 |
10 | 0.07 | |
15 | 2.10 | |
20 | 11.01 | |
25 | 12.01 | |
30 | 6.13 | |
45 | 14.27 | |
60 | 1.25 | |
42 °C; 75 rpm | 05 | 99.46* |
10 | 81.39* | |
15 | 53.58* | |
20 | 31.08* | |
25 | 3.82 | |
30 | 12.60 | |
45 | 13.18 | |
60 | 3.08 | |
37 °C; 50 rpm | 05 | 81.96* |
10 | 78.05* | |
15 | 49.66* | |
20 | 20.73* | |
25 | 2.01 | |
30 | 9.64 | |
45 | 12.59 | |
60 | 9.76 | |
37 °C; 100 rpm | 05 | 44.39* |
10 | 62.50* | |
15 | 49.04* | |
20 | 9.27 | |
25 | 2.89 | |
30 | 8.26 | |
45 | 0.24 | |
60 | 9.10 |
* = Variation considered significant (higher than 15.00%)