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. 2018 May 24;13(5):e0197323. doi: 10.1371/journal.pone.0197323

Table 8. Variation coefficients regarding the robustness evaluation of the dissolution test.

Condition Time (min) Variation coefficient (CV%)
32 °C; 75 rpm 05 12.48
10 0.07
15 2.10
20 11.01
25 12.01
30 6.13
45 14.27
60 1.25
42 °C; 75 rpm 05 99.46*
10 81.39*
15 53.58*
20 31.08*
25 3.82
30 12.60
45 13.18
60 3.08
37 °C; 50 rpm 05 81.96*
10 78.05*
15 49.66*
20 20.73*
25 2.01
30 9.64
45 12.59
60 9.76
37 °C; 100 rpm 05 44.39*
10 62.50*
15 49.04*
20 9.27
25 2.89
30 8.26
45 0.24
60 9.10

* = Variation considered significant (higher than 15.00%)