Fig. 6.

NS1-BP potentiates the therapeutic effect of irradiation on ESCC xenografts. a Volumes of tumor xenografts were measured every 3 days with calipers for 36–45 days. NS1-BP inhibited the growth of tumors in the non-treatment groups (control and NS1-BP). The mean tumor volume in the control and NS1-BP groups was 1264.6 ± 240 and 1033 ± 113 mm³, respectively (n = 6, P = 0.036, Student’s t test). After 6-Gy irradiation (control + IR and NS1-BP + IR groups), the mean tumor volume in the NS1-BP group was significantly smaller (326.6 ± 66 mm³ versus 742.3 ± 136 mm³ in the control; n = 6, P = 0.007, Student’s t test). Values represent mean tumor volume ± SD (*P < 0.05; **P < 0.01, student’s t test). b Representative images show tumor xenografts in null mice with TE-1-Control and TE-1-NS1-BP cells. Immunohistochemical staining of NS1-BP and c-Myc of tumor sections excised from mice. Lower c-Myc expression was seen in NS1-BP-overexpressing cells than in TE-1 vector control cells