Table 2.
Univariate Cox regression analysis of potential prognostic factors for ESCC patients
| Variables | Learning cohort | Validation cohort | ||
|---|---|---|---|---|
| HR (95% CI) | P* | HR (95% CI) | P* | |
| Age (years) | ||||
| ≤ 55a | 1.000 | 1.000 | ||
| > 55 | 1.075 (0.743–1.398) | 0.826 | 1.115 (0.673–1.375) | 0.747 |
| Gender | ||||
| Male | 1.000 | 1.000 | ||
| Female | 0.673 (0.512–0.887) | 0.036 | 0.596 (0.425–0.862) | 0.041 |
| WHO grade | ||||
| G1 | 1.000 | 1.000 | ||
| G2 | 1.376 (0.373–3.746) | 0.019 | 1.542 (0.538–4.137) | 0.033 |
| G3/4 | 2.479 (0.469–4.837) | < 0.001 | 2.058 (0.558–6.726) | < 0.001 |
| T category | ||||
| T2–3 | 1.000 | 1.000 | ||
| T4 | 5.475 (2.886–14.137) | 0.014 | 6.889 (2.135–19.559) | 0.008 |
| N category | ||||
| N0 | 1.000 | 1.000 | ||
| N1 | 9.963 (4.472–18.336) | < 0.001 | 12.559 (6.838–16.945) | < 0.001 |
| M category | ||||
| M0 | 1.000 | 1.000 | ||
| M1-lymb | 21.958 (11.028–67.559) | < 0.001 | 16.996 (7.459–70.137) | < 0.001 |
| CRT response | ||||
| CR | 1.000 | 1.000 | ||
| Not CR | 18.965 (13.447–78.775) | 0.007 | 22.598 (9.589–56.779 | < 0.001 |
| NS1-BP expression | ||||
| High | 1.000 | 1.000 | ||
| Low | 16.795 (9.984–52.694) | 0.002 | 21.821 (14.470–68.632) | < 0.001 |
ESCC esophageal squamous cell carcinoma, T tumor, N node, M metastases, CR complete response
*χ2 test
aMean age
bDistant lymph node metastases