Table 3.
Summary of events that resulted in dose reductions and delays
| Toxicity | Grade | Oxaliplatin, 5-FU/Leucovorin | Irinotecan |
|---|---|---|---|
| Hemoglobin | Any grade | No reduction | |
| Neutropenia | 3 (ANC 500–999/mm3) | No reduction (1 week delay) | |
| 4 (ANC ≤ 499/mm3) | 25% reduction | 25% reduction | |
| Febrile neutropenia | 3 (ANC < 1000/mm3 and body temperature ≥ 38.5 °C) | 25% reduction | 25% reduction |
| 4 (grade 3 febrile neutropenia and life threatening sepsis) | 50% reduction | 50% reduction | |
| Thrombocytopenia | 3 (25,000–50,000/mm3) | 25% reduction | 25% reduction |
| 4 (< 25,000/mm3) | 25% reduction | ||
ANC absolute neutrophil count