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The coagulation cascade is the pathway is responsible for maintaining the balance between a pro‐thrombotic and anti‐thrombotic state. Contact with a negatively charged surface or following vascular injury results in the release of tissue factor, platelet activation and activation of Factor X, followed by the conversion of fibrinogen to fibrin and the formation of a cross‐linked fibrin clot. Feedback loops cause amplification of factor activation. Ca2+: calcium ions; PL: phospholipids.
