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. 2018 Jun 8;4(6):eaat0761. doi: 10.1126/sciadv.aat0761

Scheme 1. Hydrogenation of nitroarenes with intermetallic Ni-Si catalyst Ni-phen@SiO2-1000.

Scheme 1

Reaction conditions: (A) Nitroarene (0.5 mmol), catalyst (40 mg; 4.0 mol % Ni), H2 (10 bar), 60°C, 20 hours, and 1:1 H2O/MeOH (2 ml). Isolated yields are reported unless otherwise indicated. (B to D) Nitrobenzene (0.5 mmol), Ni-phen@SiO2-1000 catalyst (40 mg; 4.0 mol % Ni), H2 (10 bar), 40°C, 20 hours, and 1:1 H2O/MeOH (2 ml). (D) Raney Ni catalyst (7.5 or 88 mg; 25 or 300 mol % Ni, respectively). a20 bar of H2, 80°C, 24 hours; bGC yields using n-hexadecane standard.