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. 2018 May 7;7(7):e1440169. doi: 10.1080/2162402X.2018.1440169

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© 2018 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 2. — CART-133 cell dose escalation. (A) Dose group and CART-133 infusion cell dose pattern in all patients. (B) Hemoglobin (Hgb), reticulocyte, CD133+ cells and CAR-gene copy numbers in PB were detected before and at serial time points after CART-133 cell infusion in each patient from every cohort. (C) Tumor biomarkers in serum from each patient were detected before and at serial time points after CART-133 cell infusion. The blue dashed line on the plots is the normal range of each tumor biomarker. Red represents the increase, and green represents the decrease. N = cell infusion cycle; n = case number.