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. 2018 Mar 13;7(7):e1440166. doi: 10.1080/2162402X.2018.1440166

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Figure 8. — Blocking the NTS/IL-8 signaling pathway inhibited HCC development and metastasis in vivo. a. The tumor size substantially shrunk in reparixin group compared to control group, but no significant difference was found in SR48692 group compared to the controls. b. The tumor size shrunk in reparixin group and SR48692+reparixin group compared to the controls. No significant difference was observed between reparixin group and SR48692+reparixin group. c. The numbers of lung metastatic nodules decreased after SR48692, reparixin or combination treatment. And the number of metastasis nodules in SR48692+reparixin group was lower than that in reparixin group d. EMT markers were analyzed among three groups, and significantly reduced expression levels of N-cadherin and β-catenin proteins was found in primary tumor tissues after SR48692, reparixin or combination treatment.