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. 2018 Mar 27;7(7):e1445459. doi: 10.1080/2162402X.2018.1445459

Figure 6.

Figure 6.

Oncolytic vaccination converts the tumor microenvironment. Immunohistochemical staining for CD3 (A), CD8a (B) and MHCI (C) of untreated tumors (n = 4), peak-boost (n = 4) (6 days after first dose of MG1-STEAP) and end-stage (STEAP vaccinated) tumors (n = 4). Tumors stained immunohistochemically for the CD3 and CD8a cell surface antigens using DAB substrate chromogen and for MHCI using AEC substrate chromogen, nuclei were counterstained with hematoxylin (scale bars = 100μm). Immunohistochemical quantification of CD3, CD8a and MHCI staining from untreated (n = 4), peak-boost (n = 4) and end-stage (n = 4) TRAMP-C2 tumors (D) (mean and SEM displayed, comparison performed using ANOVA, *p ≤ 0.05, **p ≤ 0.01,).