Table 3.
Multivariate analysis of PFS according to clinicopathological parameters and combined IDO+ cell and TAM numbers in patients with primary CNS-DLBCL
| PFS |
|||
| Variables |
HR |
95% CI |
P |
| Low IDO+ and CD68+ cell numbers | |||
| Comparison with risk factors | |||
| Normal LDH | 3.586 | 1.187–10.837 | 0.024 |
| Multifocal disease | 1.091 | 0.370–3.215 | 0.875 |
| Low IDO+ and CD68+ cell numbers | 7.618 | 2.506–23.160 | <0.001 |
| High CD204+ cell numbers | 3.223 | 1.043–9.958 | 0.042 |
| Comparison with Nottingham/Barcelona score | |||
| Nottingham/Barcelona score 3 | 3.785 | 1.170–12.246 | 0.026 |
| Low IDO+ and CD68+ cell numbers | 6.276 | 2.324–16.945 | <0.001 |
| High CD204+ cell numbers | 2.151 | 0.772–5.993 | 0.143 |
| Low IDO+ and high CD204+ cell numbers | |||
| Comparison with risk factors | |||
| Normal LDH | 2.923 | 1.017–8.399 | 0.046 |
| Multifocal disease | 1.542 | 0.474–5.018 | 0.472 |
| Low IDO+ and high CD204+ cell numbers | 3.429 | 1.143–10.287 | 0.028 |
| Low CD68+ cell numbers | 3.156 | 1.075–9.267 | 0.037 |
| Comparison with Nottingham/Barcelona score | |||
| Nottingham/Barcelona score 3 | 4.016 | 1.244–12.971 | 0.020 |
| Low IDO+ and high CD204+ cell numbers | 3.251 | 1.314–8.045 | 0.011 |
| Low CD68+ cell numbers | 3.329 | 1.168–9.484 | 0.024 |
| Low IDO+ cell number and high CD204+/CD68+ cell ratio | |||
| Comparison with risk factors | |||
| Normal LDH | 3.213 | 1.129–9.146 | 0.029 |
| Multifocal disease | 1.369 | 0.486–3.856 | 0.552 |
| Low IDO+ cell number and high CD204+/CD68+ cell ratio | 4.290 | 1.529–12.040 | 0.006 |
| Comparison with Nottingham/Barcelona score | |||
| Nottingham/Barcelona score 3 | 5.187 | 1.609–16.716 | 0.006 |
| Low IDO+ cell number and high CD204+/CD68+ cell ratio | 4.730 | 1.786–12.524 | 0.002 |
PFS, progression-free survival; HR, hazard ratio; CI, confidence interval; LDH, lactate dehydrogenase.