Table 2.

GWAS-eQTL Co-localized Loci

Chr	GWAS Locus Start	GWAS Locus End	GWAS Lead SNP	GWAS p Value	eSNP	eSNP p Value	Primary/Conditional	PPH4	Gene	Relevant Tissue/Cell Type/Developmental Period
1	2372401	2402501	rs4648845	4.03E−09	rs12037821	4.9E−04	conditional	0.87	SLC35E2	–/–/early mid-prenatal
1	8355697	8638984	rs301797	2.03E−09	rs138050288	1.8E−04	primary	0.95	RERE	–/–/–
1	30412551	30443951	rs1498232	1.28E−09	rs2015244	1.8E−08	primary	0.99	PTPRU	–/neurons /early mid-prenatal
1	163582923	163766623	rs7521492	5.64E−07	rs10799961	3.18E−11	primary	0.91	PBX1	–/–/early prenatal
1	205015255	205189455	rs16937	8.69E−07	rs12724651	7.31E−07	primary	0.89	TMEM81	–/neurons/–
					rs12031350	8.15E−06	conditional	0.87	RBBP5	–/–/–
1	214137889	214163689	rs7529073	9.69E−07	rs1431983	1.67E−04	conditional	0.93	PROX1-AS1	cerebellar hemisphere/neurons/adult
2	73194203	73900439	rs56145559	8.42E−08	rs11679809	1.85E−34	primary	0.86	ALMS1P	testis/–/–
2	110262036	110398236	rs9330316	7.69E−08	rs892464	2.35E−26	primary	0.92	SEPT10	–/–/late prenatal
2	198148577	198835577	rs6434928	1.48E−11	rs12621129	6.06E−12	primary	0.94	SF3B1	–/–/–
2	200715237	201247789	rs281768	1.78E−14	rs35220450	3.46E−14	primary	0.95	FTCDNL1, AC073043.2	–/–/adult
					rs186546506	8.77E−04	conditional	0.83	LINC01792, AC007163.3	putamen (basal ganglia)/ –/adult
2	208371631	208531731	rs2709410	5.75E−07	rs34171849	5.86E−17	primary	0.88	METTL21A	–/–/–
					rs2551656	2.85E−09	primary	0.86	CREB1	–/–/early prenatal
2	220033801	220071601	rs6707588	9.51E−07	rs13404754	1.08E−09	primary	0.92	CNPPD1	–/–/–
3	36843183	36945783	rs75968099	3.39E−12	rs9834970	1.88E−05	primary	0.94	DCLK3	nerve - tibial /neurons/infant
3	52281078	53539269	rs2535627	3.96E−11	rs6801235	2.81E−08	conditional	0.86	PPM1M	–/neurons/late prenatal
3	63792650	64004050	rs832187	2.58E−08	rs113386200	1.95E−12	primary	0.98	THOC7	–/–/–
3	135807405	136615405	rs7432375	5.27E−11	rs10935184	7.71E−25	primary	0.93	PCCB	–/–/–
4	170357552	170646052	rs10520163	1.02E−08	rs7438	1.02E−09	primary	0.97	CLCN3	–/–/–
5	45291475	46404116	rs1501357	1.24E−08	rs9292918	4.45E−05	primary	0.94	BRCAT54, RP11-53O19.1	–/–/adult
6	83779798	84407274	rs3798869	8.57E−10	rs2016358	1.19E−09	primary	0.90	SNAP91	cerebellar hemisphere/–/–
6	108875527	109019327	rs9398171	3.37E−08	rs111727905	3.84E−06	primary	0.97	ZNF259P1	–/–/early mid-prenatal
7	21485312	21545712	rs73060317	6.60E−07	rs141984481	3.59E−05	primary	0.92	SP4	–/–/early prenatal
8	8088038	10056127	rs2945232	2.03E−08	rs2980441	7.68E−69	primary	0.82	FAM86B3P	–/–/adolescent
8	26181524	26279124	rs1042992	2.27E−07	rs17055186	3.06E−24	conditional	0.91	SDAD1P1	testis/–/adult
8	38020424	38310924	rs57709857	2.32E−07	rs201999919	1.70E−07	primary	0.88	WHSC1L1	–/–/early prenatal
8	144822546	144871746	rs11784536	1.83E−07	rs12541792	6.45E−35	primary	0.90	FAM83H	esophagus - mucosa/oligodendrocytes/adolescent
9	26839508	26909408	rs10967586	4.75E−07	rs12345197	3.90E−06	primary	0.80	IFT74	–/–/–
11	46340213	46751213	rs7951870	1.97E−11	rs16938506	5.08E−05	primary	0.88	MDK	–/–/early mid-prenatal
12	57428314	57497814	rs324017	2.13E−07	rs4559	2.02E−05	conditional	0.91	STAT6	–/microglia/adolescent
14	35421614	35847614	rs77477310	1.52E−07	rs1028449	8.09E−04	primary	0.84	RP11-85K15.2	–/–/–
15	78803032	78926732	rs8042374	1.87E−12	rs7171869	1.44E−04	conditional	0.94	IREB2	–/–/early prenatal
15	84661161	85153461	rs950169	7.62E−11	rs35677834	1.54E−34	primary	0.80	LOC101929479, RP11-561C5.3	ovary/–/early mid-prenatal
15	91416560	91436560	rs4702	2.30E−12	rs4702	4.49E−13	primary	1.00	FURIN	–/endothelial cells/adolescent
16	4447751	4596451	rs6500602	2.79E−07	rs3747580	4.75E−16	primary	0.90	CORO7	–/–/–
					rs8046295	2.68E−11	primary	0.89	NMRAL1	–/–/–
16	29924377	30144877	rs12691307	1.30E−10	rs4788203	1.95E−05	primary	0.88	TMEM219	–/–/–
					rs3935873	7.46E−14	primary	0.87	INO80E	–/neurons/–
					rs4787491	1.60E−04	conditional	0.82	DOC2A	brain - cortex/neurons/adolescent
16	58669293	58691393	rs12325245	1.15E−08	rs11647976	4.83E−04	primary	0.94	CNOT1	–/–/–
17	17722402	18030202	rs8082590	6.84E−09	rs4072739	4.74E−13	primary	0.92	DRG2	–/–/–
19	11839736	11859736	rs72986630	4.64E−08	rs72986630	2.20E−14	primary	1.00	ZNF823	–/endothelial cells/early prenatal
19	19374022	19658022	rs2905426	6.92E−09	rs2965199	9.22E−36	primary	0.87	GATAD2A	–/–/–
19	50067499	50135399	rs56873913	2.19E−07	rs5023763	9.32E−05	primary	0.93	SNRNP70	–/–/–
22	41408556	42689414	rs9607782	6.76E−12	rs200447424	1.87E−04	primary	0.96	RANGAP1	–/–/–