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. 2016 Jun;57(7):3313–3322. doi: 10.1167/iovs.16-19420

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Matrix metalloproteinase 14 rescues VEGFA-induced aortic sprouting in Flk1cre/MMP14lox mice. Matrix metalloproteinase 14 was added to the aortic ring in the presence or absence of VEGFA to rescue a loss of MMP14 in flk1cre/MMP14lox mice. (A) No aortic ring sprouting occurred without VEGFA and MMP14. Limited microvessel sprouting occurred after exposure to (B) VEGFA, (C) MMP14, or (D) both VEGFA and MMP14. (E) Quantitated results from the VEGFA-induced aorta ring assay with and without the addition of MMP14.