Less blood vessel growth after implantation of VEGFA pellet in corneas of Flk1cre/Flk1mCherry/MMP14lox mice compared with Flk1mCherry/MMP14lox mice. Vascular endothelial growth factor A pellets were implanted in Flk1cre/Flk1mCherry/MMP14lox mice (B, D, F, and H) and Flk1mCherry/MMP14lox control mice (A, C, E, and G). Mice corneas were imaged at days 0, 3, 7, and 10, and the area of corneal blood vessel growth was calculated and analyzed. There were no statistically significant differences between the areas of corneal blood vessels at baseline (day 0) or day 3. (I) The areas of corneal blood vessels at days 7 and 10 were statistically significantly less in the Flk1cre/Flk1mCherry/MMP14lox mice compared with the Flk1mCherry/MMP14lox (P < 0.05).