. Author manuscript; available in PMC: 2018 Jun 8.

Published in final edited form as: Hepatology. 2014 May 27;60(1):133–145. doi: 10.1002/hep.26946

Table 2.

Effects of Diet and Genotype on Liver Injury After 5 and 10 Weeks of Dietary Administration

Time on Diet Genotype Diet	5 weeks				10 weeks
	C57BL/6		Lepr^db/db		C57BL/6		Lepr^db/db
	Chow (n=6)	High fat (n=6)	Chow (n=6)	High fat (n=5)	Chow (n=6)	High fat (n=6)	Chow (n=6)	High fat (n=6)
Steatosis	0	0	0.2 ± 0.2	2.2 ± 0.3^*^†	0	0	0.3 ± 0.2	2.8 ± 0.2^*^†
Inflammation	0.2 ± 0.2	0	0	1 ± 0^*^†	0	0.2 ± 0.2	0.3 ± 0.2	0.8 ± 0.3^*^†
Ballooning	0	0	0	0.6 ± 0.2^*^†	0	0	0	1.2 ± 0.3^*^†
NAFLD Dx	0/6	0/6	1/6	2/5	0/6	0/6	2/6	3/6
NASH Dx	0/6	0/6	0/6	3/5	0/6	0/6	0/6	3/6
TUNEL, %	0.53 ± 0.05	0.50 ± 0.09	0.72 ± 0.23	2.32 ± 1.01^*^†	0.29 ± 0.07	0.70 ± 0.24	1.30 ± 0.65	2.34 ± 0.54^*^†

Means scores for steatosis, inflammation, ballooning, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) with the ratio of mice diagnosed with NAFLD and NASH. Values are expressed as mean ± SEM.

P < 0.05 vs. dietary control;

^†

P < 0.05 vs. strain control.