Table 4.

Time-varying analysis: Warfarin use and stroke outcomes, bleeding outcomes, and all-cause mortality by sex, age, race and dialysis modality among older adults (≥ 65 years) undergoing dialysis with newly diagnosed atrial fibrillation

	Any stroke	Ischemic stroke	Major bleeding	Gastrointestinal bleeding	All-cause Mortality
	HR, 95% CI	HR, 95% CI	HR, 95% CI	HR, 95% CI	HR, 95% CI
Sex
Male (n=2,491)	0.80 (0.57–1.11)	0.74 (0.50–1.08)	1.29 (1.08–1.55)*	1.06 (0.74–1.54)	0.72 (0.62–0.84)
Female (n=3,274)	0.98 (0.77–1.26)	0.97 (0.73–1.29)	1.67 (1.44–1.93)*	1.00 (0.70–1.41)	0.72 (0.63–0.83)
Age category
65 to < 75 y (n=3,062)	0.96 (0.74–1.25)	0.89 (0.66–1.20)	1.47 (1.27–1.71)	0.97 (0.70–1.35)	0.73 (0.64–0.84)
75 to <85 y (n=2,157)	0.88 (0.64–1.22)	0.88 (0.61–1.28)	1.52 (1.25–1.84)	1.09 (0.71–1.66)	0.68 (0.57–0.80)
≥ 85 y (n=546)	0.74 (0.31–1.77)	0.82 (0.31–2.12)	1.57 (1.01–2.45)	1.24 (0.46–3.30)	0.85 (0.60–1.21)
Race
White (n=3,617)	0.87 (0.67–1.12)	0.86 (0.64–1.16)	1.59 (1.38–1.83)	0.99 (0.72–1.35)	0.74 (0.65–0.84)
Non-white (n=2,148)	1.00 (0.73–1.35)	0.92 (0.65–1.30)	1.36 (1.11–1.65)	1.10 (0.72–1.67)	0.69 (0.57–0.83)
Modality
Hemodialysis (n=5,572)	0.89 (0.73–1.09)	0.84 (0.66–1.07)*	1.49 (1.33–1.68)	1.03 (0.80–1.33)	0.72 (0.65–0.80)
Peritoneal dialysis (n=193)	1.93 (0.82–4.50)	2.59 (1.06–6.32)*	1.60 (0.89–2.88)	1.07 (0.31–3.62)	0.66 (0.40–1.10)

^*P-value for effect modification statistically significant < 0.05.

Analysis was based on the adjusted Cox regression analysis in the IPTW weighted sample.