Table 3.

Suggestive (p-value < 0.005) S-PrediXcan results for skin predicted gene expression levels.

Gene	Chr	Position	Band	Skin Tissue	z-score†	p-value	R2‡	Q§	N Variants¶	Model N††	SKAT p-value	SKAT N‡‡
DCAF4	14	73404680–73425478	14q24.2	Non sun-exposed	3.45	5.52×10−4	0.045	0.002	2	33	0.242	10
OR10A3	11	7960139–7961010	11p15.4	Sun exposed	3.40	6.86×10−4	0.012	0.018	1	45	0.150	8
ANKRD7	7	117864712–117882784	7q31.31	Sun exposed	3.22	0.001	0.008	0.042	1	43	NA
OBFC1	10	105642542–105651971	10q24.33	Sun exposed	−3.18	0.002	0.043	1.73×10−4	1	25	0.424	3
ZNF580	19	56153418–56154836	19q13.42	Non sun-exposed	3.09	0.002	0.249	6.00×10−13	2	61	0.341	1
GSTM1	1	110231746–110232965	1p13.3	Non sun-exposed	−3.08	0.002	0.020	0.032	1	44	0.769	2
TMEM253	14	21567096–21571883	14q11.2	Sun exposed	−3.08	0.002	0.009	0.034	2	36	NA
TMEM229B	14	67940444–67940444	14q24.1	Sun exposed	3.06	0.002	0.047	1.00×10−4	1	37	0.253	1
HSPE1	2	198364721–198368187	2q33.1	Non sun-exposed	−3.03	0.002	0.051	0.002	1	18	NA
PIGC	1	172410967–172411374	1q24.3	Sun exposed	−3.03	0.003	0.079	6.89×10−7	1	61	0.528	2
NYAP1	7	100084515–100091399	7q22.1	Non sun-exposed	3.03	0.002	0.086	5.31×10−5	1	29	0.103	3
QRICH2	17	74273284–74300497	17q25.1	Sun exposed	−3.01	0.003	0.101	2.01×10−8	2	41	0.279	11
NANP	20	25596850–25597061	20p11.21	Non sun-exposed	2.99	0.002	0.052	0.001	2	62	1	2
PNKP	19	50364549–50370425	19q13.33	Sun exposed	2.98	0.003	0.034	7.32×10−4	1	5	0.052	6
UBQLN4	1	156011427–156018299	1q22	Non sun-exposed	2.97	0.003	0.035	0.008	1	11	0.135	2
SLPI	20	43881680–43881682	20q13.12	Sun exposed	2.96	0.003	0.204	3.78×10−16	1	47	0.004	1
ZNF432	19	52537202–52538294	19q13.41	Non sun-exposed	2.95	0.003	0.096	1.82×10−5	1	82	0.733	4
ZNF471	19	57027720–57037309	19q13.43	Sun exposed	2.94	0.003	0.140	3.32×10−11	3	44	1	3
CTC1	17	8131548–8151342	17p13.1	Sun exposed	−2.91	0.004	0.016	0.011	1	14	0.336	10
RNF222	17	8294023–8301144	17p13.1		−2.91	0.003	0.028	0.014	1	43	NA
DNAJB1	19	14625576–14640134	19p13.12	Sun exposed	−2.89	0.004	0.121	4.68×10−9	1	31	NA
SLC6A11	3	10916706–10976854	3p25.3	Non sun-exposed	−2.86	0.004	0.102	9.65×10−6	3	105	0.603	4

^†Z-score for association of predicted gene expression with increasing risk of keloids. Direction of effect of the expression is indicated by sign of the z-score+

^‡Performance prediction R²

^§Prediction performance q-value.

^¶Number of SNPs included in the prediction model for that gene available in the summary statistics.

^††Number of SNPs used to construct the prediction model for the gene in the tissue of interest using the GTEx data.

^‡‡Number of SNPs within the gene included in the SKAT analysis. NA = gene was not available in this analysis