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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: J Cell Physiol. 2018 Mar 30;233(9):6319–6326. doi: 10.1002/jcp.26482

Fig. 1. Generation of BAG3 haplo-insufficient mouse.

Fig. 1

(A) A schematic of generation of heterozygous BAG3 knockout mice using recombination between LoxP sites on the BAG3 gene. Numbers on protein cartoon indicate amino acid positon and numbers 1-4 on transcript indicate intron boundaries. (B) Representative western blot of BAG3 levels in both cBAG3+/+ and cBAG3+/− mice with glyceraldehyde 3-phosphate dehydrogenase (GAPDH) as the housekeeping protein. (C) Graph showing quantification of BAG3 levels in cBAG3+/+ (n = 8) and cBAG3+/− (n = 6) mice. *** p <0.0001.