(A) Representative M-mode echocardiograms of cBAG3+/+ and cBAG3+/− mice at 4, 8, 10 and 12 weeks of age. (B & C) Quantification of ejection fraction (B) and percent fractional shortening (C) at 4, 8, 10 and 12 weeks of age. For cBAG3+/+ mice n = 10, 6, 4 and 3 at each time point respectively and for cBAG3+/− mice n = 8, 6, 5 and 4 at each time point respectively. ** p <0.0001, * p = 0.0004