Table 1.
Percent Cell Length | Percent Cell Length With ISO | |
---|---|---|
cBAG3+/+ | 4.96±0.16 (15) | 11.86±0.41 (11) |
cBAG3+/− | 4.95±0.27 (16) (NS) | 10.66±0.35 (14)*** |
Systolic [Ca2+]i (nM) | Systolic [Ca2+]i (nM) With ISO | |
cBAG3+/+ | 215±14 (11) | 633±43 (15) |
cBAG3+/− | 202±11 (16) (NS) | 428±28 (12)*** |
Diastolic [Ca2+]i (nM) | Diastoic [Ca2+]i (nM) With ISO | |
cBAG3+/+ | 96±7 (11) | 91±7 (15) |
cBAG3+/− | 98±7 (16) (NS) | 94±6 (12) |
Transient Amplitude (%) | Transient Amplitude (%) With ISO | |
cBAG3+/+ | 18.6±1.2 (11) | 58.6±2.5 (15) |
cBAG3+/− | 17.9±1.0 (16) (NS) | 46.2±2.2 (12)** |
Units of [Ca2+]iI transient amplitude: % increase of fura intensity ratio.
Contractility and Ca2+ handling were not different at baseline (NS) but were reduced in the presence of isoproterenol (ISO). n= number of cells in 3 separate preparations; values are mean ± SE;
p < 0.0001.
p = 0.001.