Figure 3.
Sections of developing human fetal uterine corpus immunostained for ESR1 at the ages indicated (A-D). At all stages (8 to 18 weeks) ESR1 is undetectable in the uterine epithelium. At 18 weeks, the stroma is ESR1-positive. (E & F) are sections of grafts of 10 week (E) and 13 week (F) human fetal uterine corpus grown for 4 weeks in DES-treated ovariectomized hosts and immunostained for ESR1. Note induction of epithelial ESR1.