Participants perceiving untreated fluctuations (UF group) score higher on all three clinician-rated scales of depression (HAM-D-17, MADRS, IDS-C) and a self-rated scale of depression (BDI). However, they do not report worse quality of life (PDQ-8) or more severe impairment in ADL (UPDRS-II, measured “off” medication). They also do not exhibit worse neurologist-rated motor impairment (UPDRS-III, measured “on” medication). P-values derived from Mann-Whitney U tests. NS. = not significant. ** = p < 0.01.