Table 2.
Poisson Regression: Suicidality and UPDRS, Self-Report, or Mood Fluctuation Data (n=223)
| Suicide Scale Question (Outcome) | Independent | Odds ratio | 95% CI | Z-value | p |
|---|---|---|---|---|---|
| HAM-D-17 | UPDRS-II: On vs. off total score difference | 1.04 | 0.95–1.12 | 0.99 | 0.322 |
| UPDRS-III: Motor examination total score | 1.03 | 1.01–1.05 | 2.59 | 0.01** | |
| Endorsed Mood Fluctuations (non-UPDRS) | 3.66 | 1.64–7.68 | 3.32 | *** | |
| Self-reported no on/off symptoms (reference) | |||||
| Self-reported treated on/off symptoms | 1.16 | 0.47–2.77 | 0.34 | 0.736 | |
| Self-reported untreated on/off symptoms | 3.73 | 1.62–8.45 | 3.15 | 0.002** | |
| MADRS | UPDRS-II: On vs. off total score difference | 1.03 | 0.95–1.09 | 0.70 | 0.482 |
| UPDRS-III: Motor examination total score | 1.03 | 1.01–1.05 | 2.87 | 0.004** | |
| Endorsed Mood Fluctuations (non-UPDRS) | 3.14 | 1.59–5.92 | 3.42 | *** | |
| Self-reported no on/off symptoms (reference) | |||||
| Self-reported treated on/off symptoms | 1.08 | 0.50–2.28 | 0.22 | 0.826 | |
| Self-reported untreated on/off symptoms | 3.93 | 1.98–7.76 | 3.94 | *** | |
| IDS-C | UPDRS-II: On vs. off total score difference | 1.07 | 0.98–1.15 | 1.69 | 0.092 |
| UPDRS-III: Motor examination total score | 1.03 | 1.01–1.06 | 2.60 | 0.009** | |
| Endorsed Mood Fluctuations (non-UPDRS) | 3.84 | 1.66–8.31 | 3.29 | *** | |
| Self-reported no on/off symptoms (reference) | |||||
| Self-reported treated on/off symptoms | 1.23 | 0.47–3.07 | 0.44 | 0.657 | |
| Self-reported untreated on/off symptoms | 3.80 | 1.58–8.97 | 3.04 | 0.002** | |
| BDI | UPDRS-II: On vs. off total score difference | 1.04 | 0.93–1.14 | 0.73 | 0.463 |
| UPDRS-III: Motor examination total score | 1.03 | 1.00–1.06 | 2.19 | 0.028* | |
| Endorsed Mood Fluctuations (non-UPDRS) | 2.50 | 0.86–6.32 | 1.82 | 0.068 | |
| Self-reported no on/off symptoms (reference) | |||||
| Self-reported treated on/off symptoms | 0.49 | 0.14–1.48 | −1.20 | 0.232 | |
| Self-reported untreated on/off symptoms | 2.46 | 0.92–6.20 | 1.87 | 0.061 |
Each model includes the following additional covariates: current depressive disorder (DSM-IV TR diagnosis), history of alcohol dependence, LEDD, disease duration, and sex. Odds ratios and confidence intervals represent the exponentiated coefficients and interval endpoints. Z-value was computed as the regression coefficient divided by its standard error.
*
p<0.05,
**
p<0.01,
***
p<0.001.