Table 1.

Summary of studies assessing locomotor sensitization to repeated cocaine administration in adolescent and adult female rats.

Age on First Day of Treatment Paradigm	Strain	Dose	Treatment Paradigm	Reference	Result
Adult ~PND 71	Wistar	15 mg/kg	8 days cocaine, day 19 challenge	[15]	Sensitization
Adult 175-200g	Wistar	20, 40 mg/kg	5 days cocaine	[16]	Sensitization
Adult ~PND 111	Wistar	10 mg/kg	10 days cocaine	[17]	Sensitization
PND 41	Sprague Dawley	3, 7.5, 15 mg/kg	1 day saline, 6 days cocaine, day 11 challenge	[7]	Sensitization on day 7 (7.5mg/kg), day 11 (7.5, 15 mg/kg)
PND 33	Sprague Dawley	10, 20 mg/kg	4 days cocaine, day 6 challenge with 10 mg/kg cocaine	[8]	Sensitization on day 6
PND 20	Sprague Dawley	30 mg/kg day 1, 20 mg/kg day 2	2 days cocaine	[12]	Sensitization on day 2 compared to 20 mg/kg first cocaine exposure group
PND 25	Sprague Dawley	1-17.8 mg/kg	4 cocaine doses every 15 min on 6 test days once weekly	[9]	Sensitization trend; stats not available
70-80g (~PND25- 27)	Sprague Dawley	1-17.8 mg/kg	4 cocaine doses every 15 min on 6 test days once weekly	[13]	Sensitization
PND 34	Sprague Dawley	30 mg/kg day 1, 20 mg/kg day 2	2 days cocaine	[11]	No sensitization; Significant in first 10-min bin
PND 32	Sprague Dawley	5 and 15 mg/kg	5 days cocaine, day 20 challenge	[10]	Sensitization trend, no significance on day 20
PND 27	Long Evans	7 and 15 mg/kg	two rounds of 5 days cocaine separated by 2 days	[14]	Sensitization on day 4, 5, and 9 to 15 mg/kg