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. 2018 May 17;10(6):1991–2004. doi: 10.1016/j.stemcr.2018.04.020

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© 2018 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Numerical Simulation of Firing Patterns with Variable Channel Levels

(A) Simulation (blue) and fluorescence trace (black) of a neuron showing tonic firing.

(B) Simulation (blue) and fluorescence trace (black) of the same neuron shown in (A) approaching the transition to depolarization block under strong stimulus.

(C–E) Each trace shows the number of APs in a 500-ms interval as a function of the optogenetic stimulus strength (g_m). Maximum conductances of the indicated channels were varied from 0.67- to 1.5-fold basal level. (C) Variation in Na_V level. (D) Variation in K_V (delayed rectifier) level. (E) Variation in K_V7 level. The changes in the F-I curve that came with lower K_V7 conductance phenotypically matched the differences and similarities between SOD1 A4V and control neurons.