Figure 6.

Anti-leukemic Activity of CTLs Primed By CD40L^high CD4⁺ iPS-T Cell-Conditioned DCs

(A) In vivo anti-leukemia effect. NSG mice were subcutaneously injected with mixtures of K562-A24-Luc-WT1 minigene and either saline or WT1-specific CTLs. Upper panel: tumor burden was measured weekly by bioluminescence imaging. Lower panel: the average tumor size for each group from day 0 to 42 is shown. Error bars represent ± SD. ^∗p < 0.05 by unpaired Student's t test (two-tailed).

(B) Kaplan-Meier survival curves for treated and control mice. ^∗p < 0.05 by the log rank (Mantel-Cox) test. WT1-CTL, n = 10; no treatment, n = 5.