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. 2018 May 24;10(6):1705–1720. doi: 10.1016/j.stemcr.2018.04.024

Figure 6.

Figure 6

Disruption of RA Signaling in Adult NSPCs Decreases Their Population

(A) Paradigm of tamoxifen injection and collection of experimental animals.

(B–D) Representative images depicting RFP+ cells in the (B) control and (C) mutant SGZ. Quantification of RFP+ cells in the DG of each genotype is in (D). Scale bar, 100 μm.

(E–M) Fewer RFP+ (E and F) stem cells, intermediate progenitors (G and H ), and (I and J) neuroblasts are obsevred in the mutant SGZ as in compared to control animals. Quantification of RFP+ cells (K) stem cells, (L) intermediate progenitors (IP) and (M) neuroblasts (NB) in the two genotypes. Scale bar, 50 μm. Data represented as mean ± SEM, ∗p ≤ 0.05, ∗∗p ≤ 0.01, ∗∗∗p ≤ 0.001, n = 3.