FIG. 6.

Effects of flow velocity on cancer cell-endothelium interactions. Percent of cells undergoing each defined state of adhesion for each flow condition on TNF-α stimulated endothelium. A trend can be seen in the data as the mean flow velocity increased. The number of non-interacting cells increased significantly with increasing flow rate, while the number of firmly adherent cells decreased significantly. At the high mean velocity, there was a large jump in the number of non-interacting cells. At this high velocity, there was virtually no cancer cell immobilization, and very little rolling behavior observed. The results are presented in the form: mean ± standard deviation. The percentage of cell adhesion states was obtained from 3 devices per each flow velocity group (n = 3, *: p < 0.05).