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. 2018 Jun 8;8:8780. doi: 10.1038/s41598-018-26646-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The miRNA expression profiles in the heart of rats. (a) Heat maps show significantly up- and down-regulated mRNAs in the heart of rats fed HFD and control rats for 24 weeks (n = 7 in each experiment). miRNA expression profiles were clustered hierarchically. (b) Volcano Plot for differential miRNA expression in the heart of rats. The green dost represent the most significantly upregulated miRNAs (more than five-fold, P < 0.05), including miR-3583-3p, -410-5p, -146b-3p, -764-5p, -330-5p, and -324-3p, in the heart of rats fed HFD for 24 weeks. The arrow indicates miR-322-5p. (c) qPCR analysis of the six most-up-regulated miRNAs in the heart of rats. All results are standardized to the levels of 18S rRNA and the means ± SD of three experiments (n = 6 in each experiment). *P < 0.05; **P < 0.01 relative to control (normal group).