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. 2018 Jun 8;8:8780. doi: 10.1038/s41598-018-26646-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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miR-410-5p from the kidney and adipose tissues promotes cardiac fibrosis. (a) The levels of pre-miR-410 (a) and miR-410-5p (b) were determined by qPCR in different tissues of rats fed normal diet and HFD, respectively. All results are standardized to the levels of 18S rRNA and the means ± SD of three experiments (n = 10 in each experiment). *P < 0.05; **P < 0.01 relative to control (normal group). (c,d) The levels of miR-410-5p in serum (c) and exosomes (d) of rats fed normal diet and HFD. These results are the means ± SD of three experiments (n = 10 in each experiment). *P < 0.05 relative to control. (e) The levels of miR-410-5p in the heart of rats fed normal diet with kidney- or adipocyte-specific overexpression of miR-410. NPHS2-miR-410, kidney-specific overexpression; aP2-miR-410, adipocyte-specific overexpression. *P < 0.05 relative to negative control (NC). All results are standardized to the levels of 18S rRNA and the means ± SD of three experiments (n = 10 in each experiment). (f) The levels of miR-410-5p in exosomes of rats fed normal diet with kidney- or adipocyte-specific overexpression of miR-410. These results are the means ± SD of three experiments (n = 10 in each experiment). *P < 0.05; **P < 0.01 relative to NC. (g,h) Masson’s staining of heart in rats (Left panels). Quantitative analysis of fibrotic area (Right panel). These results are means ± SD of three experiments (n = 10 in each experiment). **P < 0.01 relative to NC. Scale bar, 20 μm.