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. 2018 Jun 8;8:8759. doi: 10.1038/s41598-018-27053-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Rapamycin delivered into the hippocampus 30 minutes before test session disrupts object location long term memory retrieval. Rats were bilaterally infused with rapamycin (Rapa) or saline (Veh) into the hippocampus 30 min before a test session carried out 24 h after the training in object location task. *p < 0.05, Veh vs. Rapa groups, unpaired Student’s t Test, n = 7-8. Data are expressed as mean ± SEM of the discrimination index.