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. 2018 Jun 8;9:2233. doi: 10.1038/s41467-018-04641-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Development of the infant GI microbiota is highly structured in time. Each panel shows a non-metric multidimensional scaling (nMDS) plot based on Bray–Curtis distances, for each of the 12 infants. For each model there is a highly significant relationship between the primary axis of variation and time since birth (for all tests p ≪ 0.001, mean R² = 0.7 (range 0.47–0.86), linear regression). Dots are colored according to the bar above the panels. Early and late refer to the order in which the samples were collected (see Table 1 for days of first and last sampling)