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. 2018 Jun 8;8:8775. doi: 10.1038/s41598-018-26274-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Global pairwise gene interaction network of the exome identified genes. Gene co-expression and direct protein-protein interactions are shown as a combined network. Family 8-specific genes are shown in red ovals, family 6 - in blue ovals. The names of the genes with significant enrichment or aggregated association of rare variants in SLE cases are shown in red italic. Genes associated after removing linked variants (r² < 0.1), adjustment by 10 principal components and genomic control, and multiple test correction are highlighted with a star. Note the high connectivity within the network of the SLE-associated genes. Blue-filled ovals correspond to the genes with known immunity-related Mendelian disorders (OMIM data), green-filled - to the genes with published genome-wide significant associations with autoimmune and autoinflammatory disorders, yellow-filled - with other genome-wide significant immunity-related traits (Table S4).