Table 4.

Large π-conjugation-controlled site-selective asymmetric ketimine-alkenylation/ring-expansion

Reactions were carried out on a 0.20 mmol scale of 4 using 5  mol% Ni(OTf)₂, 7.5  mol% ligand and 2 (0.30 mmol) in unpurified TFE (2.0  mL) at 50 ^oC in a test tube, which was open to air. Isolated yields and ee’s were determined by chiral HPLC