Table 1.

Patient and tumor characteristics comparison n = 139

	< 5-years group	%	≥ 5-years group	%	p
Primary breast tumor§
Adenocarcinoma
Ductal	51	86	26	93	0.490
Lobular	8	14	2	7
Differentiation
Well	3	5	1	3	0.503
Moderate	34	61	22	73
Poor	19	34	7	23
Surgical removal
Breast conserving	42	45	25	60	0.140
Mastectomy	51	55	17	40
Receptor status
ER positive
No	9	20	3	14	0.737
Yes	36	80	19	86
PR positive
No	15	35	7	35	1.000
Yes	28	65	13	65
Her2/Neu positive
No	24	69	9	60	0.746
Yes	11	31	6	40
ER/PR negative
No	36	84	18	90	0.706
Yes	7	16	2	10
Systemic treatment
Neoadjuvant chemo
No	93	97	41	95	0.645
Yes	3	3	2	5
Adjuvant chemo
No	39	41	19	44	0.713
Yes	57	59	24	56
Post op hormonal therapy
No	66	69	26	61	0.341
Yes	30	31	17	39
Post op radiotherapy
No	32	33	13	30	0.845
Yes	64	67	30	70
Breast cancer liver metastases
Sync
Synchronous	7	7	4	10	0.738
Metachronous	87	93	38	90
Mean interval months between primary and BCLM ± SD	50 ± 47 months		43 ± 29 months		0.026*
Mean number of BCLM ± SD	2 ± 2		2 ± 2		0.803
Mean maximum tumor size ± SD, mm	33 ± 17		37 ± 20		0.312
Distribution
Bilateral	29	32	17	44	0.232
Unilateral	62	68	22	56
Concomitant extra-hepatic disease
No	63	66	35	81	0.071
Yes	33	34	8	19
Preoperative chemotherapy
No	30	31	11	26	0.551
Yes	66	69	32	74
Hepatectomy
Mean age at hepatectomy ± SD	53 ± 11 years		48 ± 10 years		0.208
Timing of hepatectomy
Year < 2000	36	38	17	40	0.852
Year > 2000	60	62	26	60
Extent of resection
Limited resection (< 3 segments)	38	40	19	44	0.710
Major resection (≥ 3 segments)	58	60	24	56
Type of resection
Anatomical	32	33	17	40	0.657
Wedge	35	37	13	30
Anatomical+wedge	29	30	13	30
Histopathology
Mean number of resected metastases ± SD	3 ± 2		2 ± 2		0.023*
Solitary tumor
No	57	63	19	46	0.090
Yes	34	37	22	54
Mean maximum size ± SD, mm (M)	30 ± 26		26 ± 16		0.374
Resection margin
R0	52	58	25	66	0.435
R+	38	42	13	34
Hormonal receptor status
ER−	40	46	7	21	0.021
ER+	48	54	26	79
PR−	57	65	24	73	0.516
PR+	31	35	9	27
Her2/neu−	60	70	23	72	1.000
Her2/neu+	26	30	9	28
Triple negative (ER, PR, HER2/NEU)
No	66	75	28	85	0.329
Yes	22	25	5	15
Lymphatic embolus
No	28	35	21	66	0.003*
Yes	53	65	11	34
Vascular embolus
No	33	37	24	63	0.011*
Yes	56	63	14	37
Regional lymph node invasion
Negative for tumor cells	9	41	4	57	0.667
Positive for tumor cells	13	59	3	43
Distant lymph node invasion
Negative for tumor cells	12	75	1	100	1.000
Positive for tumor cells	4	25	0	0
Post hepatectomy
Postoperative chemotherapy
No	35	37	9	21	0.078
Yes	61	64	34	79
Hormonal therapy after resection
No	63	66	11	26	0.000*
Yes	33	34	32	74
Monoclonal therapy after resection
No	72	75	25	58	0.071
Yes	24	25	18	42
Recurrence
No	58	60	15	35	0.006*
Yes	38	40	28	65
Repeat hepatectomy
No	95	99	25	58	0.000*
Yes	1	1	18	42

^§Referring center for hepatectomy, primary usually is treated in a different hospital, *p-value < 0.05