Figure 1.
In Vivo Firing Rate of pChIs Reflects Changes in Excitatory Input, with Pauses Accompanying Withdrawal of Excitation
(A) Firing of pChIs with (left, purple) or without (right, blue) short-latency-evoked action potentials before a pause. Top: example; bottom: average, pause (blue arrow), rebound (green arrow). Firing rate correlation, r2 = 0.78, p < 0.001 (n = 4–5).
(B) Mean ± SEM for amplitude (top) and duration (bottom) of pause and rebound.
(C and D) Top: example striatal LFP; middle top: mean ± SEM of inverted LFP (iLFP); middle: mean firing rate (black) ± SEM (gray) in pChIs (n = 5, n = 9); bottom: mean firing rate (black) ± SEM (gray) in SPNs (n = 5) aligned to maximum of spontaneous iLFP (dashed red line) (C) or contralateral cortical stimulation (0.2 Hz; solid red lines) (D). Purple dashed line, firing rate maxima; shaded blue, pChI firing rate below baseline, a “pause.”
(E) Phase plot of firing rates for ChIs and SPNs. Data were extracted during slow LFP oscillation in (D).