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. 2018 Jun 6;98(5):918–925.e3. doi: 10.1016/j.neuron.2018.04.027

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© 2018 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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I_Kr Underlies Hyperpolarization Induced by Excitatory Input Withdrawal in ChIs

(A) Representative membrane potential in presence of TTX (1 μM) and I_h blocker Zd7288 (50 μM) without (dark gray) and with (light gray) resting membrane potential (RMP) restored to −55 mV (n = 6) during trapezoid current injections.

(B) Representative membrane potential in presence of TTX (black) and either (gray) I_h blocker Zd7288 or Kv7.2/7.3 blocker XE-991 (100 μM, n = 6). RMP was held at pre-drug condition.

(C and D) Mean ± SEM of amplitude of hyperpolarization below RMP (C) or ratio of trough:peak (black versus gray vertical dashed lines in B) (D), normalized to control. Riluzole, 100 μM; cadmium, 200 μM; CsCl, 2 mM; Zd7288, 50 μM; 4-AP, 1 mM; TEA, 20 mM. n = 4–6. Typical traces shown in Figure S3. ^∗∗∗p < 0.001, one-sample t test versus control.