Table 1.
Evaluation of the therapeutic efficacy of the pomegranate peel extract (PPE) and nystatin against oral candidiasis in the rats
| Groups | Oral candidiasis induced | Number of cured | |||
|---|---|---|---|---|---|
| Day 0 | Day 5 | Day 10 | Day 15 | ||
| PPE-1 (500 mg/kg/d BW) | Infected (n=5) | 0 | 3 | 4 | 5 |
| PPE-2 (250 mg/kg/d BW) | Infected (n=5) | 0 | 2 | 3 | 5 |
| PPE (125 mg/kg/d BW) | Infected (n=5) | 0 | 2 | 3 | 5 |
| Nystatin | Infected (n=5) | 0 | 2 | 2 | 4 |
| Positive control | Infected (n=5) | 0 | 0 1 dead | 0 1 dead | 0 1 dead |
| Non-immunosuppressed rats managed with PPE-2 (250 mg/kg/d BW) | Non-infected (n=5) | Not infected (negative culture) and without symptom | Not infected (negative culture) and without symptom | Not infected (negative culture) and without symptom | Not infected (negative culture) and without symptom |
| Immunosuppressed but neither infected nor treated | Non-infected (n=5) | Not infected (negative culture) and without symptom | Not infected (negative culture) and without symptom | Not infected (negative culture) and without symptom | Not infected (negative culture) and without symptom |