Figure 4.

Effect of EPC Exosomes on Plasma Cytokine/Chemokine Levels in Septic Mice

Mice were subjected to sham or CLP and injected with EPC exosomes (2 mg protein/kg body weight) or control PBS (same volume) at 4 hr after CLP surgery. Plasma cytokine IL-6 (A), IFNγ (B), TNF-α (C), IL-10 (D), and chemokine MCP-1 (E) levels were determined by mouse cytokine and chemokine array at 24 hr after CLP. *p < 0.05 compared with sham group; ^#p < 0.05 compared with CLP group. n = 3–4 mice per group. Results are represented as mean ± SE.