Figure 7.

Effect of EPC Exosomal miR-126-3p and 5p on LPS-Induced HMVEC Target Expression and CLP-Induced Mortality

Protein levels of VCAM1 (A) and HMGB1 (B) in HMVECs were measured by western blot. α-Tubulin served as an internal control. *p < 0.05 compared with control group; ^#p < 0.05 compared with LPS group; **p < 0.05 compared with LPS+ EPC exosomes group. The results represent the means ± SE of three independent experiments. CD-1 mice were subjected to CLP and treated with EPC exosomes, miR-126-reduced EPC exosomes (2 mg protein/kg body weight), or PBS. Survival rate was monitored for a total of 168 hr (7 days) (C). n = 15–16 mice per group.